When administering blood products is an everyday occurrence, nurses need to be aware of the potential risks and adverse outcomes of transfusions. Understand the difference between and treatment requirements of a potential transfusion-associated circulatory overload and transfusion-related acute lung injury as well as other adverse reactions. What does the evidence show regarding thresholds of transfusing blood products? What is the importance of understanding the need for irradiated, CMV-negative, or washed products? You’ll see an APL patient in disseminated intravascular coagulopathy requiring multiple blood products to gain knowledge on how you can recognize and manage adverse events of blood product administration.